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研究热点分析:脂毒性 Lipotoxicity 1994-2010

放大字体  缩小字体 发布日期:2015-07-31  来源:科学网  浏览次数:532618
市场营销讯:http://www.gopubmed.org/web/gopubmed/1?WEB03pvul3p9thxaI2pI5bI00h01000j100200010505 documents semantically analyzedTop Y

http://www.gopubmed.org/web/gopubmed/1?WEB03pvul3p9thxaI2pI5bI00h01000j100200010

505 documents semantically analyzed

 
Top Years Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000300012001')">2009   81
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000301012001')">2010   71
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000302012001')">2007   62
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000303012001')">2008   59
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000304012001')">2006   48
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000305012001')">2004   45
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000306012001')">2005   32
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000307012001')" timeout="null" removehook="null" mouseoutregistered="true">2002   30
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000308012001')">2003   23
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111000309012001')">2001   19
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030a012001')" timeout="null" removehook="null" mouseoutregistered="true">2000   9
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030b012001')" timeout="null" removehook="null" mouseoutregistered="true">1998   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030c012001')" timeout="null" removehook="null" mouseoutregistered="true">1999   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030d012001')" timeout="null" removehook="null" mouseoutregistered="true">1996   2
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030e012001')">1997   1
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030f012001')" timeout="null" removehook="null" mouseoutregistered="true">1995   1
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011100030g012001')">1994   1
 
1 2 3 ...12 
Top Journals Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100300012001')">Diabetes   35
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100301012001')">Biochim Biophys Acta   27
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100302012001')">Am J Physiol-endoc M   18
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100303012001')">J Biol Chem   17
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100304012001')">J Lipid Res   14
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100305012001')">Endocrinology   13
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100306012001')">Diabetologia   12
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100307012001')">Diabetes metab   12
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100308012001')">Biochem Bioph Res Co   9
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111100309012001')">Curr Opin Lipidol   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030a012001')">Hepatology   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030b012001')">P Natl Acad Sci Usa   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030c012001')">Int J Obesity   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030d012001')">metabolism   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030e012001')">Diabetes Obes metab   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030f012001')">M S-med Sci   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030g012001')">Ann Endocrinol-paris   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030h012001')">Biochem Soc T   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030i012001')">Febs Lett   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011110030j012001')">Nippon Rinsho   3
1 2 3 ...12 
 
1 2 3 ...143 
Top Terms Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200300012001')">Insulin   318
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200301012001')">receptor binding   309
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200302012001')">Insulin   307
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200303012001')">Fatty Acids   305
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200304012001')">Animals   299
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200305012001')">Humans   264
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200306012001')">metabolism   259
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200307012001')">metabolic process   259
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200308012001')">Lipids   237
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111200309012001')">Insulin Resistance   216
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030a012001')">Glucose   214
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030b012001')">Obesity   181
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030c012001')">Triglycerides   168
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030d012001')">Oxides   160
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030e012001')">Tissues   158
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030f012001')">Proteins   156
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030g012001')">Pancreatitis   131
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030h012001')">Diabetes Mellitus, Type 2   129
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030i012001')">insulin secretion   123
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011120030j012001')">positive regulation of insulin secretion   122
1 2 3 ...143 
 
1 2 
Top Countries Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300300012001')">USA   188
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300301012001')">Japan   32
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300302012001')">Canada   28
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300303012001')">China   24
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300304012001')">Italy   24
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300305012001')">France   21
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300306012001')">United Kingdom   20
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300307012001')">Sweden   17
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300308012001')">Spain   14
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111300309012001')">Switzerland   14
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030a012001')">Germany   14
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030b012001')">Netherlands   13
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030c012001')">Australia   13
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030d012001')">Israel   9
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030e012001')">Belgium   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030f012001')">Poland   7
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030g012001')">Austria   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030h012001')">Denmark   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030i012001')">El Salvador   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011130030j012001')">South Korea   4
1 2 
 
1 2 3 ...9 
Top Cities Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400300012001')">Dallas   28
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400301012001')">St. Louis   18
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400302012001')">Pisa   13
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400303012001')">Paris   12
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400304012001')">San Antonio   12
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400305012001')">New York   11
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400306012001')">Toronto   11
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400307012001')">Tokyo   10
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400308012001')">Boston   9
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111400309012001')">Bethesda   9
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030a012001')">Cambridge   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030b012001')">Jerusalem   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030c012001')">Maastricht   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030d012001')">Cleveland   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030e012001')">Lund   7
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030f012001')">Düsseldorf   7
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030g012001')">Brussels   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030h012001')">Durham   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030i012001')">Vancouver   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011140030j012001')">Tsukuba   6
1 2 3 ...9 
 
1 2 3 ...97 
Top Authors Publications  
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500300012001')">Unger R   19
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500301012001')">Del Prato S   10
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500302012001')">Marchetti P   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500303012001')">Lee Y   8
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500304012001')">Cusi K   7
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500305012001')">Poitout V   7
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500306012001')">Schrauwen P   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500307012001')">Schaeffer J   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500308012001')">Le Roith D   6
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j1005000010011000000111500309012001')">Defronzo R   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030a012001')">Bajaj M   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030b012001')">Vidal-Puig A   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030c012001')">Torres N   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030d012001')" timeout="null" removehook="null" mouseoutregistered="true">Wheeler M   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030e012001')">Robertson R   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030f012001')">Hesselink M   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030g012001')">Zhou Y   5
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030h012001')">Lupi R   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030i012001')">Gorski J   4
nmouseover="gui_moe(this, 1000, '1?WEB03pvul3p9thxaI3oI6pI00h01000j100500001001100000011150030j012001')" timeout="null" removehook="null" mouseoutregistered="true">Shimano H   4
1 2 3 ...97 

 

什么是“脂毒性”学说?

     在肥胖和2型糖尿病患者中常存在血游离脂肪酸(FFA)、甘油三酯(TG)和胆固醇升高等脂代谢紊乱。近年来,众多证据表明,脂代谢紊乱在2型糖尿病发病中居于重要地位,FFA升高是2型糖尿病发病的独立危险因素。

  胰岛素抵抗和胰岛素分泌缺陷是发生2型糖尿病的两大要素,FFA升高对二者均有显著影响。FFA是目前公认的致胰岛素抵抗因子,它可影响胰岛素信号转导的多个环节,如抑制胰岛素受体酪氨酸的磷酸化以及磷脂酰肌醇3激酶和葡萄糖转运蛋白4的活性等,进而引起胰岛素抵抗。FFA还可通过多种机制影响胰岛B细胞功能,如FFA可影响前胰岛素原启动子的转录、活化,抑制胰岛素基因表达和胰岛素合成;增加胰腺内TG含量;促使胰岛细胞凋亡等。FFA通过上述机制触发胰岛素抵抗,损害胰岛B细胞功能,进而导致糖尿病的发生,这就是近年提出的糖尿病发病的“脂毒性”学说。

 

 



 
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